The jurisdiction of office of the Commissioner of Customs (Preventive), Mumbai extends over an area of about 370 kms. starting from 'Dahanu' in Maharashtra on the Indian coastline in the North upto 'Srivardhan' in the South, covering greater mumbai, Thane, Palghar and Raigad.

The Rummaging & Intelligence wing situated at 11th & 12th Floor, New Custom House Ballard Estate, Mumbai - 400 001, has the jurisdiction of the areas under the Mumbai Docks & Harbour, Nhava Sheva, Sahar Airport, Sahar Air Cargo Complex, Santacruz Electronics Export Processing Zone (SEEPZ), CFS Mulund, Diamonds Plaza Customs Clearance Centre (DPCCC) and the Mumbai city.

The Marine & Preventive wing Hqrs. situated at 100, Everest House, New Marine Drive, Marine Lines, Mumbai-400 007, has jurisdiction over the areas comprising of 2 Divisions in the districts of Thane and Raigad for anti-smuggling operations. The District Thane area is covered by the Bassein Division while the District Raigad area is covered by the Alibagh Division. There are 4 numbers of active minor ports in the area namely (i) Revdanda; (ii) Dharamtar; and (iii) PNP Jetty; (all three falling in Alibaug Division) and (iv) Dahnau (falling in Bassein Division), this wing covers 220 Kms long coastline along with Thane & Raigad Districts. A part from above for Anti-smuggling operations M & P Wing is having jurisdiction with R&I in Mumbai City.

In addition to this Commissionerate also attends to post seizure work of Mumbai Zonal Unit (MZU) of the Directorate of Revenue Intelligence (DRI) like prosecution, safe keeping of seized goods, disposal confiscated goods, etc.